diff --git a/cura/CuraApplication.py b/cura/CuraApplication.py
index bdf26c889f..df78cdec7b 100755
--- a/cura/CuraApplication.py
+++ b/cura/CuraApplication.py
@@ -773,7 +773,10 @@ class CuraApplication(QtApplication):
     def discardOrKeepProfileChanges(self) -> bool:
         has_user_interaction = False
         choice = self.getPreferences().getValue("cura/choice_on_profile_override")
-        if choice == "always_discard":
+        if not self._currently_loading_files:
+            # opening from a file; don't show dialog and KEEP the profile
+            self.discardOrKeepProfileChangesClosed("keep")
+        elif choice == "always_discard":
             # don't show dialog and DISCARD the profile
             self.discardOrKeepProfileChangesClosed("discard")
         elif choice == "always_keep":